Quick Answer: How Is The Family Of A Person With Osteogenesis Imperfecta Affected?

How does osteogenesis imperfecta affect a person’s life?

Milder cases may involve only a few fractures over a person’s lifetime.

Additional complications can involve hearing loss, heart failure, spine issues, and deformities.

Osteogenesis imperfecta can sometimes be life-threatening if it occurs in babies either before or shortly after birth..

Is Oi a disability?

Most people with OI experience physical disability. OI also can cause weak muscles, brittle teeth, a curved spine, and hearing loss. Most forms of OI are caused by abnormal genes that are passed down from one or both parents to their children. There are currently 11 types of OI.

What is OI type 4?

Osteogenesis imperfecta type IV is a moderate type of osteogenesis imperfecta (OI; see this term), a genetic disorder characterized by increased bone fragility, low bone mass and susceptibility to bone fractures.

Can osteogenesis imperfecta be passed down?

Whether a person has OI due to a new mutation or an inherited genetic change, an adult with the disorder can pass the condition down to future generations. In autosomal dominant inherited OI, a parent who has OI has one copy of a gene mutation that causes OI.

Does osteogenesis imperfecta affect a certain ethnic group?

The incidence rate is similar in people with milder forms of OI that become apparent later in life. OI affects all genders, races and ethnic groups equally.

What is the cause of OI?

Mutations in several genes can lead to OI. About 80%–90% of OI cases are caused by autosomal dominant mutations in the type 1 collagen genes, COL1A1 and COL1A2. Mutations in one or the other of these genes cause the body to make either abnormally formed collagen or too little collagen.

What is an OI baby?

Your child has been diagnosed with osteogenesis imperfecta (OI). This is a rare condition that causes bones to be very thin and delicate so they break (fracture) easily. OI is sometimes called brittle bone disease. There are four types of OI that range from mild to severe.

Where does osteogenesis imperfecta affect the body?

Osteogenesis imperfecta, also known as brittle bone disease, is a genetic disorder that causes bones to break easily without cause. The condition affects the body’s ability to produce collagen, a protein in the body’s connective tissue.

How long does someone with osteogenesis imperfecta live?

Most children born with type I OI live normal, healthy lives into adulthood. Less severe symptoms do not affect life expectancy. Most OI-related deaths result from respiratory failure due to weak lungs. The most severe types will result in death at birth or soon after.

Can you walk with osteogenesis imperfecta?

Some people with Type I OI are very mildly affected. They may have only a few fractures. They are of average or even above-average height; are able to walk and run; and have signs of OI that are barely noticeable, such as blue-tinted sclera or loose joints.

Where is osteogenesis imperfecta most common?

OI type II is estimated to occur in one in 60,000 live births. The overall prevalence of all types of OI is estimated at . 5 per 10,000 individuals in the United States. Approximately 20,000 to 50,000 individuals in the United States have OI.

Is Osteogenesis Imperfecta painful?

Background: Pain is a common symptom of osteogenesis imperfecta (OI) among children and adolescents.

Does brittle bone disease affect teeth?

Osteogenesis Imperfecta (OI) is always associated with bone fragility. In addition, OI may affect the growth of the jaws and may or may not affect the teeth. About half of the people who have OI have teeth that appear normal, and their major concerns are routine care.

What is Oi medical condition?

Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the bones. The term “osteogenesis imperfecta” means imperfect bone formation.

What is wrong with Byron the Baxter boy?

When you listen to 3-year-old Byron Baxter laugh and talk, you’d never know anything was wrong with him. But he was born with a rare condition called osteogenesis imperfecta, or brittle bone disease.

Who is most likely to get osteogenesis imperfecta?

Osteogenesis imperfecta occurs equally in girls and boys and among all racial and ethnic groups, affecting six to seven people in every 100,000. An estimated 20,000 to 50,000 people in the U.S. have the condition. The estimated number varies greatly because milder forms of osteogenesis imperfecta can go undiagnosed.

Does osteogenesis imperfecta get worse with age?

It causes bones to break easily. In type 3 OI, your child’s body produces enough collagen but it’s poor quality. Your child’s bones can even begin to break before birth. Bone deformities are common and may get worse as your child gets older.