What Does Alkaline Phosphatase Do In Bone?

What does alkaline phosphatase do?

Alkaline phosphatase (ALP) is an enzyme in a person’s blood that helps break down proteins.

The body uses ALP for a wide range of processes, and it plays a particularly important role in liver function and bone development..

What is the treatment for high alkaline phosphatase?

A reduction in serum ALP was also seen in the euparathyroid subjects (2.4 +/- 0.77 to 2.2 +/- 0.64 mu kat/l, p = 0.03). This study indicates that treatment with active vitamin D is effective in reducing the increased bone turnover seen in subjects with both primary and secondary HPT.

What is alkaline phosphatase normal range?

The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and sex. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.

Can fatty liver cause high alkaline phosphatase?

Fatty liver linked to obesity often causes a rise in liver transaminases but not a solitary rise in alkaline phosphatase. Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.

What medications cause high levels of alkaline phosphatase?

The following drugs may affect the level of alkaline phosphatase in the blood:Allopurinol.Antibiotics.Anti-inflammatory medicines.Birth control pills.Certain diabetes medicines.Chlorpromazine.Cortisone.Male hormones.More items…•

What foods increase alkaline phosphatase?

The diet containing phosphorus, healthy fats, Zn, vitamin B12 and vitamin A can be started to increase alkaline phosphatase level.

Why is alkaline phosphatase elevated in bone disease?

Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia.

What are the symptoms of high alkaline phosphatase?

Why do I need an alkaline phosphatase test?Nausea and vomiting.Weight loss.Tiredness.Weakness.Jaundice, a condition that causes your skin and eyes to turn yellow.Swelling and/or pain in your abdomen.Dark-colored urine and/or light-colored stool.Frequent Itching.

What happens if alkaline phosphatase is high?

High ALP usually means that either the liver has been damaged or a condition causing increased bone cell activity is present. If other liver tests such as bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) are also high, usually the increased ALP is caused by liver damage or disease.

Should I worry about elevated alkaline phosphatase?

High levels Higher-than-normal levels of ALP in your blood may indicate a problem with your liver or gallbladder. This could include hepatitis, cirrhosis, liver cancer, gallstones, or a blockage in your bile ducts.

Can high alkaline phosphatase cause itching?

Itching sometimes gets worse during pregnancy or if you’re undergoing hormone replacement therapy. Serum alkaline phosphatase (ALP). People with itch related to liver disease may have elevated ALP.

Can vitamin D deficiency cause elevated alkaline phosphatase?

Thus, vitamin D deficiency is usually accompanied by normal blood levels for calcium and phosphorus, high-normal or elevated levels of PTH, normal to elevated levels of total alkaline phosphatase, a low 24-hour urine calcium excretion rate, and low levels of total 25(OH)D.